Room: MNT 367
Office: (613) 562-5800 ext. 4282
Work E-mail: firstname.lastname@example.org
NOTE: Dr. Kenny is currently accepting graduate students for both the Masters of Science and Doctoral program. Learn more and reach out at hepru.ca.
Dr. Glen P. Kenny is a Full Professor of Physiology at the University of Ottawa and holds a University Research Chair in Human Environmental Physiology. He is a Fellow of the Canadian Academy of Health Sciences and the American College of Sports Medicine and is director of the Human and Environmental Physiology Research Unit (HEPRU). Over the past 27 years, Dr. Kenny has been a principal investigator of numerous large projects directed primarily at understanding the human heat stress response. His work (funded by CIHR, NSERC, Health Canada, Government of Ontario, Ontario Centers of Excellence, Mitacs and others) is unique in that it employs the world’s only direct calorimeter (a device for making very precise measurements of body heat exchange) to assess the physiological consequences of heat stress under a wide array of environmental conditions in different population groups including elite athletes, warfighters, first responders, workers, individuals with chronic disease (i.e., diabetes, hypertension, obesity), burn patients, elderly and others. His work has been instrumental in creating new and advanced knowledge, policies, standards and guidelines for physical activity and work in hot environments that includes exposure limits, hydration requirements, clothing systems, cooling interventions, heat management strategies that include advanced monitoring technologies, and others. In addition, he has led numerous randomized clinical trials evaluating exercise interventions in managing the health and fitness of individuals including heat-vulnerable workers. He has authored over 450 peer-reviewed papers on human thermoregulation as well as physical activity and health.
Exercise and environmental physiology,
Global heating and population health
Heat stress in vulnerable populations – older adults and individuals with chronic disease
Worker health and safety in adverse environments
Heat management and monitoring technologies
Dr. Kenny’s current work consists of well-established independent yet highly interconnected directions of research.
Research Focus 1. Understanding the mechanisms and controllers governing the regulation of heat loss in the human system – from the end-organ to the whole-body response. This research is directed at understanding the mechanisms underpinning the regulation of heat loss responses of skin blood flow and sweating as assessed by techniques such as intra-dermal microdialysis and whole-body calorimetry. This includes assessing the separate and combined influence of nonthermal sensory receptor activation (baroreceptors, metaboreceptors, etc.) on end-organ function (i.e., skin vasculature, sweat glands).
Research Focus 2. Elucidating the complex cellular response of the human heat stress response. Our work aims to evaluate the human heat stress response from the cellular level as defined by the assessment of responses related to autophagy, apoptosis, inflammation, and the heat shock response (i.e. heat shock proteins). This includes assessing complex cellular mechanisms utilizing techniques such as western blotting to analyze protein content and quantitative real-time polymerase chain reaction (qRT-PCR) to assess transcriptional regulation of these stress response systems during heat stress.
Research Focus 3. Defining the body’s physiological capacity to dissipate heat. This work is directed at explicating the integrative mechanisms governing human heat exchange during heat stress as a function of the independent and interactive effects inter-individual factors (e.g. age, sex, chronic disease (diabetes, hypertension), race, other) and intra-individual factors (modifiable within an individual over relatively short periods) both within (e.g. hydration, fitness, other); and beyond an individual’s control (e.g. heat exposure duration, sleep, other) during rest and physical activity in the heat.
Research Focus 4. Defining heat health protection policies and guidelines. We are conducting leading-edge research aimed at delineating the environmental and human factors affecting a person’s ability to live and work in the heat that includes the evaluation of physiological characteristics that contribute to increased heat vulnerability in the general population and workers. Work involves assessing the integrated physiological responses under specific situational laboratory-based studies representative of real-work conditions (e.g. simulate conditions such as elderly person sitting indoors during day-long heat wave, worker performing prolonged work in the heat) to obtain a comprehensive measure of the heat stress response in heat-vulnerable population groups including workers. The data is used to generate algorithms that are subsequently validated within the field for the creation of policies and guidelines to protect health and prevent disease exacerbated by heat.
Research Focus 5. Create heat protection technologies to safeguard health and safety. A key thrust of the HEPRU research program is the development of advanced heat management solutions in the form of technologies to manage and monitor heat strain in vulnerable population groups and workers facilitated by the exploitation of the high-resolution data acquired from our laboratory- and field-based physiological studies.
- Director, Human and Environmental Physiology Research Unit
- Fellow of the Canadian Academy of Health Sciences
- Fellow of the American College of Sports Medicine
- Affiliate Investigator, Clinical Epidemiological Program of the Ottawa Hospital Research Institute
- Member of the American Physiological Society
- Member of the American College of Sports Medicine
- Member of the Canadian Society for Exercise Physiology
- Exercise-heat tolerance in middle-aged-to-older mean with type 2 diabetes. Notley SR, Akerman A, Friesen BJ, Sigal RJ, Flouris AD, Boulay P, Kenny GP. Acta Diabetologica. https://doi.org/10.1007/s00592-021-01684-z. Online ahead of print.
- Heat strain in children during unstructured outdoor physical activity in a continental summer climate. McGarr GW, Saci S, King KE, Topshee S, Richards BJ, Gemae MR, McCourt ER, Kenny GP. Temperature (Austin). 2020 Aug 12;8(1):80-89.
- Time following ingestion does not influence the validity of telemetry pill measurements of core temperature during exercise-heat stress: The journal Temperature toolbox. Notley SR, Meade RD, Kenny GP. Temperature (Austin). 2020 Sep 2;8(1):12-20.
- Impaired autophagy following ex vivo heating at physiologically relevant temperatures in peripheral blood mononuclear cells from elderly adults. McCormick JJ, King KE, Côté MD, Meade RD, Akerman AP, Kenny GP. J Therm Biol. 2021 Jan;95:102790.
- Effects of short-term heat acclimation on whole-body heat exchange and local nitric oxide synthase- and cyclooxygenase-dependent heat loss responses in exercising older men. Fujii N, McGarr GW, Notley SR, Boulay P, Sigal RJ, Amano T, Nishiyasu T, Poirier MP, Kenny GP. Exp Physiol. 2021 Feb;106(2):450-462.
- Effects of exercise-heat stress on circulating stress hormones and interleukin-6 in young and older men. Kaltsatou A, Notley SR, Kenny GP. Temperature (Austin). 2020 May 24;7(4):389-393.
- Myths and methodologies: Reliability of forearm cutaneous vasodilatation measured using laser-Doppler flowmetry during whole-body passive heating. Gemae MR, Akerman AP, McGarr GW, Meade RD, Notley SR, Schmidt MD, Rutherford MM, Kenny GP. Exp Physiol. 2020 Nov 27. doi: 10.1113/EP089073.
- Regional variation in the reliability of sweat rate measured via the ventilated capsule technique during passive heating. Rutherford MM, Akerman AP, Notley SR, Meade RD, Schmidt MD, Kenny GP.Exp Physiol. 2020 Nov 24. doi: 10.1113/EP089074. Online ahead of print.
- Effect of exercise-heat acclimation on cardiac autonomic modulation in type 2 diabetes: a pilot study. Macartney MJ, Notley SR, Herry CL, Sigal RJ, Boulay P, Kenny GP. Appl Physiol Nutr Metab. 2020 Nov 17:1-4.
- Myths and methodologies: Reliability of non-invasive estimates of cardiac autonomic modulation during whole-body passive heating. Akerman AP, Meade RD, Notley SR, Rutherford MM, Kenny GP. Exp Physiol. 2020 Nov 16. doi: 10.1113/EP089069.
- Type 2 diabetes does not exacerbate body heat storage in older adults during brief, extreme passive heat exposure. Poirier MP, Notley SR, Boulay P, Sigal RJ, Friesen BJ, Malcolm J, Flouris AD, Kenny GP. Temperature (Austin). 2020 Mar 16;7(3):263-269.
- Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease. McCormick JJ, Dokladny K, Moseley PL, Kenny GP. J Appl Physiol (1985). 2021 Jan 1;130(1):1-9.
- TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous post-occlusive reactive and thermal hyperemia. Fujii N, Kenny GP, McGarr GW, Amano T, Honda Y, Kondo N, Nishiyasu T. Am J Physiol Regul Integr Comp Physiol. 2020 Oct 21.
- KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults. McGarr GW, Muia CM, Saci S, Fujii N, Kenny GP. Microvasc Res. 2021 Jan;133:104096.
- Impact of uncomplicated controlled hypertension on thermoregulation during exercise-heat stress. Akerman AP, Notley SR, Sigal RJ, Boulay P, Ruzicka M, Friesen BJ, Kenny GP.J Hum Hypertens. 2020 Oct 14. doi: 10.1038/s41371-020-00402-6. Online ahead of print.
- The relative contribution of α- and β-adrenergic sweating during heat exposure and the influence of sex and training status. Amano T, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N. Exp Dermatol. 2020 Dec;29(12):1216-1224.
- Do sex differences in thermoregulation pose a concern for female athletes preparing for the Tokyo Olympics? Notley SR, Racinais S, Kenny GP. Br J Sports Med. 2020 Oct 1:bjsports-2020-102911. doi: 10.1136/bjsports-2020-102911. Online ahead of print.
- Ageing attenuates the effect of extracellular hyperosmolality on whole-body heat exchange during exercise-heat stress. Meade RD, Notley SR, Rutherford MM, Boulay P, Kenny GP. J Physiol. 2020 Nov;598(22):5133-5148.
- Effects of L-type voltage-gated Ca2+ channel blockade on cholinergic and thermal sweating in habitually trained and untrained men. Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Am J Physiol Regul Integr Comp Physiol. 2020 Nov 1;319(5):R584-R591.
- Physiological factors characterizing heat-vulnerable older adults: A narrative review. Meade RD, Akerman AP, Notley SR, McGinn R, Poirier P, Gosselin P, Kenny GP. Environ Int. 2020 Nov;144:105909.
- Whole-body heat exchange in women during constant- and variable-intensity work in the heat. Notley SR, D'Souza AW, Meade RD, Richards BJ, Kenny GP. Eur J Appl Physiol. 2020 Dec;120(12):2665-2675.
- Heat shock protein 90 modulates cutaneous vasodilation during an exercise-heat stress, but not during passive whole-body heating in young women. McGarr GW, Fujii N, Schmidt MD, Muia CM, Kenny GP. Physiol Rep. 2020 Aug;8(16):e14552.
- Ageing augments β-adrenergic cutaneous vasodilatation differently in men and women, with no effect on β-adrenergic sweating. Fujii N, McGarr GW, Amano T, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP. Exp Physiol. 2020 Oct;105(10):1720-1729.
- Does the iontophoretic application of bretylium tosylate modulate sweating during exercise in the heat in habitually trained and untrained men? Amano T, Sekihara S, Fujii N, Kenny GP, Inoue Y, Kondo N. Exp Physiol. 2020 Oct;105(10):1692-1699.
- Regulation of autophagy following ex vivo heating in peripheral blood mononuclear cells from young adults. McCormick JJ, King KE, Côté MD, McManus MK, Topshee SM, Hsu HS, Fujii N, Kenny GP. J Therm Biol. 2020 Jul;91:102643.
- Variability Predictors of Vasospasm in Subarachnoid Hemorrhage: A Feasibility Study. Rodriguez RA, Herry CL, English SW, Ramsay T, Seely AJE, Kenny GP, Shamy M. Can J Neurol Sci. 2020 Jul 20:1-7.
- Heart rate variability in older workers during work under the Threshold Limit Values for heat exposure. Kaltsatou A, Flouris AD, Herry CL, Notley SR, Macartney MJ, Seely AJE, Kenny GP. Am J Ind Med. 2020 Sep;63(9):787-795.
- Heart rate variability in older men on the day following prolonged work in the heat. Macartney MJ, Notley SR, Meade RD, Herry CL, Kenny GP. J Occup Environ Hyg. 2020 Sep;17(9):383-389.
- Effect of aerobic fitness on the relation between age and whole-body heat exchange during exercise-heat stress: a retrospective analysis. Notley SR, Meade RD, Kenny GP. Exp Physiol. 2020 Sep;105(9):1550-1560.
- Evidence for age-related differences in heat acclimatisation responsiveness. Notley SR, Meade RD, Akerman AP, Poirier MP, Boulay P, Sigal RJ, Flouris AD, Kenny GP. Exp Physiol. 2020 Sep;105(9):1491-1499.
- Sex-differences in cholinergic, nicotinic, and β-adrenergic cutaneous vasodilation: Roles of nitric oxide synthase, cyclooxygenase, and K+ channels. Fujii N, McGarr GW, Ghassa R, Schmidt MD, McCormick JJ, Nishiyasu T, Kenny GP. Microvasc Res. 2020 Sep;131:104030.
- The Relation between Age and Sex on Whole-Body Heat Loss during Exercise-Heat Stress. D'Souza AW, Notley SR, Kenny GP. Med Sci Sports Exerc. 2020 Oct;52(10):2242-2249.
- Heat Exchange in Young and Older Men during Constant- and Variable-Intensity Work. Notley SR, Meade RD, D'Souza AW, Rutherford MM, Kim JH, Kenny GP. Med Sci Sports Exerc. 2020 Dec;52(12):2628-2636.
- Exercise Thermoregulation in Prepubertal Children: A Brief Methodological Review. Notley SR, Akerman AP, Meade RD, McGarr GW, Kenny GP. Med Sci Sports Exerc. 2020 Nov;52(11):2412-2422.
- Does α1-adrenergic receptor blockade modulate sweating during incremental exercise in young endurance-trained men? Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. Eur J Appl Physiol. 2020 May;120(5):1123-1129.
- Regional influence of nitric oxide on cutaneous vasodilatation and sweating during exercise-heat stress in young men. Schmidt MD, McGarr GW, Muia CM, Fujii N, Amano T, Kenny GP. Exp Physiol. 2020 May;105(5):773-782.
- Significant Dose-Response between Exercise Adherence and Hemoglobin A1c Change. Benham JL, Booth JE, Dunbar MJ, Doucette S, BoulÉ NG, Kenny GP, Prud'homme D, Sigal RJ. Med Sci Sports Exerc. 2020 Sep;52(9):1960-1965.
- Cardiac autonomic modulation in type 1 diabetes during exercise-heat stress. Macartney MJ, Notley SR, Herry CL, Seely AJE, Sigal RJ, Kenny GP. Acta Diabetol. 2020 Aug;57(8):959-963.
- Blunted circulating irisin in adults with type 1 diabetes during aerobic exercise in a hot environment: a pilot study. McCormick JJ, Notley SR, Yardley JE, Sigal RJ, Kenny GP. Appl Physiol Nutr Metab. 2020 Jun;45(6):679-682.
- Diminished heart rate variability in type 2 diabetes is exacerbated during exercise-heat stress. Macartney MJ, Notley SR, Herry CL, Seely AJE, Sigal RJ, Kenny GP. Acta Diabetol. 2020 Jul;57(7):899-901.
- Intradermal Administration of Atrial Natriuretic Peptide Attenuates Cutaneous Vasodilation but Not Sweating in Young Men during Exercise in the Heat. McGarr GW, Fujii N, Muia CM, Nishiyasu T, Kenny GP. Skin Pharmacol Physiol. 2020;33(2):86-93.