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In addition to being a key storage site of energy reserves, adipose tissue is now recognized as a crucial player in various biological functions. The long-term objective of Dr. Imbeault’s research program is to understand the regulation of growth and secretory function of adipose tissue using an integrative approach from the molecular and cellular to the human level. His research activities focus on how environmental influences (for example, exercise and nutritional interventions, hypoxia and pollutants) affect adipose tissue metabolism. Overall, this work will provide a more extensive conceptual background to understand the pathophysiology, treatment and prevention of obesity and its related disorders.
- Canadian Obesity Network
- Institut de recherche de l’Hôpital Montfort
- Adipose tissue metabolism
Beyond being the primary storage site for excess energy, white adipose tissue is an organ involved in a wide range of biological functions. To maintain these functions, it has intrinsic oxygen needs that must be met. Using primary cell cultures and/or adipose tissue biopsies, we investigate how a reduction in oxygen availability (or hypoxia) affects adipose tissue metabolism and secretory functions. This work will provide further insights into the cellular and systemic responses of humans to natural environmental stress as well as into pathological conditions (e.g., sleep apnea) of oxygen deprivation.
Persistent organic pollutants (POPs) are a wide range of synthetic chemicals that have an intrinsic resistance to natural degradation. A large fraction of these environmental contaminants accumulate for years in adipose tissue, the most important lipid-storage site of the human body. We study the effect of POP exposure on adipose tissue functions to better understand the established link between POP exposure and the development of obesity and Type 2 diabetes in humans.
- Mahat B, Chassé É, Mauger J-F and Imbeault P. Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis. Journal of Translational Medicine 14:212 DOI: 10.1186/s12967-016-0965-y, 2016.
- Pépin A and Imbeault P. Trekking en altitude : influence sur le métabolisme énergétique et astuces nutritionnelles. Nutrition, science en évolution, 13(3): 19-22, 2016.
- Barsalani R, Riesco É, Perreault K, Imbeault P, Brochu M and Dionne IJ. Variation in C-reactive protein following weight loss in obese insulin resistance postmenopausal women: is there an independent contribution of lean body mass? Experimental and Clinical Endocrinology & Diabetes 123(3): 198-203, 2015.
- Seabert TA, Pal S, Pinet BM, Haman F, Robidoux MA, Imbeault P, Krümmel EM, Kimpe LE and Blais JM. Elevated contaminants contrasted with potential benefit of omega-3 fatty acids in wild food consumers of two remote First Nations communities in northern Ontario, Canada. PLoS One 9(3): e90351, 2014.
- Myre M and Imbeault P. Persistent organic pollutants meet adipose tissue hypoxia: does cross-talk contribute to inflammation during obesity? Obesity Reviews 15(1): 19-28, 2014.
- Pal S, Blais JM, Robidoux MA, Haman F, Krümmel EM, Seabert T and Imbeault P. The association of type 2 diabetes and insulin resistance/secretion with persistent organic pollutants in two First Nations communities in northern Ontario. Diabetes and Metabolism 39(6): 497-504, 2013.
- Babinsky M & Imbeault P. Le regain pondéral après une restriction calorique: des adipocytes persistants. Nutrition, science en évolution, 10(3): 21-22, 2013.
- Gagnon-Arpin I, Makvandi E, Imbeault P, Batal M and Bouchard L. Le surplus de poids chez les francophones et les anglophones. Revue canadienne de santé publique 104 (6 Suppl 1): S21-25, 2013.
- Imbeault P, Makvandi E, Batal M, Gagnon-Arpin I, Grenier J, Chomienne MH and Bouchard L. Physical inactivity among Francophones and Anglophones in Canada. Canadian Journal of Public Health 104 (6 Suppl 1): S26-30, 2013.
- Mauriège P, Imbeault P, Doucet E, Lacaille M, Langin D, Alméras N, Després JP and Tremblay A. Weight loss and regain in obese individuals : a link with adipose tissue metabolism indices? Journal of Physiology and Biochemistry, 2013 Sep;69(3):497-505. doi: 10.1007/s13105-013-0237-8. Epub 2013 Jan 27.
- Imbeault P, Findlay CS, Robidoux MA, Haman F, Blais JM, Tremblay A, Springthorpe S, Pal S, Seabert T, Krümmel EM, Maal-Bared R, Tetro JA, Pandey S, Sattar S and Filion LG. Dysregulation of cytokine response in Canadian First Nations communities: is there an association with persistent organic pollutant levels? PLoS One 7(7): e39931, 2012.
- Chapados NA, Casimiro C, Robidoux MA, Haman F, Batal M, Blais JM and Imbeault P. Increased proliferative effect of organochlorine compounds on human preadipocytes. Molecular and Cellular Biochemistry 365(1-2): 275-278, 2012.
- Drapeau S, Doucet É, Rabasa-Lhoret R, Brochu M, Prud’homme D and Imbeault P. Improvement in insulin sensitivity after weight loss does not affect hyperinsulinemia-induced reduction in total and high molecular weight adiponectin: a MONET study. Applied Physiology, Nutrition and Metabolism 36(2): 191-200, 2011.
- Imbeault P, Haman F, Blais JM, Pal S, Seabert T, Krümmel EM and Robidoux MA. Obesity and type 2 diabetes prevalence in adults from two remote First Nations communities in northwestern Ontario, Canada. Journal of Obesity 2011: 267509-267514, 2011.
- Elisha B, Karelis AD, Imbeault P and Rabasa-Lhoret R. Effect of acute hyperinsulinemia on total and high molecular weight adiponectin concentration in metabolically healthy but obese postmenopausal women: a Montreal Ottawa New Emerging Team (MONET) study. Diabetes and Metabolism 36(4): 319-321, 2010.
- Blondin D, Dépault I, Imbeault P, Péronnet F, Imbeault M-A and Haman F. Effects of two glucose ingestion rates on substrate utilization during moderate-intensity shivering. European Journal of Applied Physiology 108(2): 289-300, 2010.
- Kasbia GS, Arneson JT and Imbeault P. No effect of oral administration of Momordica charantia Linn., on glycemia, energy expenditure and appetite: A pilot study in overweight men. Journal of Ethnopharmacology. 126(1): 127-133, 2009.
- Imbeault P, Dépault I and Haman F. Cold exposure increases adiponectin levels in men. Metabolism 58(4): 552-559, 2009.
- Imbeault P. Environmental influences on adiponectin levels in humans. Applied Physiology, Nutrition and Metabolism, 32: 505-511, 2007.
Conferences and Presentations
- Pépin A, Chassé É, Mahat B, Mauger J-F and Imbeault P. Modulation of appetite levels during acute intermittent hypoxia without changes in plasma leptin concentrations in humans. Applied Physiology Metabolism and Nutrition 41: S34, 2016. (Canadian Nutrition Society, Gatineau-Ottawa, Canada).
- Mahat B, Chassé É, Mauger J-F and Imbeault P. Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis. FASEB Journal 30 (Suppl 1) 758.6, 2016 (Experimental Biology, SanDiego, CA, USA).
- Imbeault P. Persistent organic pollutants: emerging factors for obesity and type 2 diabetes prevalence? Canadian Journal of Diabetes 39, Suppl 1, S49, 2015 (National Obesity Summit, Toronto, Canada).
- Chassé É, Mahat B, Mauger J-F and Imbeault P. The effects of intermittent hypoxia, a simulating model of obstructive sleep apnea, on lipid levels in healthy humans. Canadian Journal of Diabetes 39, Suppl 1, S45, 2015 (National Obesity Summit, Toronto, Canada).
- Myre M and Imbeault P. Inflammatory responses to hypoxia and persistent organic pollutants in human adipocytes. Canadian Journal of Diabetes 37, Suppl 2, S241, 2013 (National Obesity Summit, Vancouver, Canada).